Research Central: NANO SOMA® and Circadian Rhythms
In this edition of Research Central, we’ll be exploring a study by Dr. PR Raghavan, the creator of NANO SOMA®, which examines how Metadichol® (the key ingredient in NANO SOMA) supports the healthy expression of genes involved in regulating the body’s natural circadian rhythm.*
Specifically, this research examines five essential circadian-related genes in human cells: CLOCK, BMAL1, CRY1, PER1, and PPARGC1A.Read on for a breakdown of the findings.
How Does the Circadian Rhythm Work at the Cellular Level?
The circadian rhythm is an approximately 24-hour ‘inner clock’ that helps coordinate essential functions in the body, such as sleep, hormone activity, metabolism, and immune function.
And while we often associate this process with the brain, the individual cells throughout our bodies also have their own internal timekeeping systems. The cellular clocks in our cells rely on a network of genes and proteins that work together to regulate the timing of various biological processes.
What the Paper Investigated
The study, Metadichol®-induced expression of circadian clock transcription factors in human fibroblasts, examined how Metadichol® (NANO SOMA®) may affect five specific genes involved in circadian regulation: CLOCK, BMAL1, CRY1, PER1, and PPARGC1A.
Each gene plays a specific role in the body’s cellular timekeeping systems.
For example, the CLOCK and BMAL1 genes work together to switch on other genes involved in the body’s internal clock, while CRY1 and PER1 help control when that activity slows down. PPARGC1A helps connect this internal clock with how our cells produce and use energy.
To investigate, human cells were exposed to different amounts of Metadichol for 24 hours. Then, these results were compared to the activity of these same genes in cells that had not been exposed to Metadichol.
The Findings
Several circadian-related genes showed changes after being exposed to Metadichol (NANO SOMA). At the highest concentration tested, three genes in particular showed notable increases in their expression:
CRY1: Approximately 4.1-fold increase.
CLOCK: Approximately 3.2-fold increase.
PPARGC1A: Approximately 3-fold increase.
BMAL1 and PER1 remained relatively close to their baseline levels.
These findings are interesting because CRY1 and CLOCK help regulate the body’s internal clock, while PPARGC1A helps connect this clock with how our cells use energy.
The Connection to Cellular Energy
One particularly interesting finding involved the approximate 3-fold increase in the expression of PPARGC1A, a gene associated with PGC-1α, a protein involved in cellular energy metabolism and mitochondrial function.
Mitochondria are often called the powerhouses of our cells because they produce the energy our cells need to function.
The protein PGC-1α helps regulate how our cells produce and use energy, while also working with the body’s internal clock to coordinate these processes throughout the day.
The study found that in the presence of Metadichol, these cells increased their activity of the gene responsible for producing PGC-1α considerably. While this is an interesting finding, further research is needed to determine whether this reliably leads to improvements in cellular energy production. Nonetheless, this finding does corroborate NANO SOMA user testimonials, many of which emphasize experiencing increased energy* in their day-to-day lives.
Sirtuins and Healthy Aging
The research also discusses sirtuins, a family of proteins involved in metabolism, cellular stress responses, and certain aspects of our aging processes.
Two sirtuins highlighted are SIRT1 and SIRT6, both of which interact with pathways involved in circadian regulation.
The paper references earlier Metadichol research reporting an increase in the gene expression for SIRT1 (approximately 6.9-fold) and for SIRT6 (approximately 4.3-fold) at the highest concentration tested.
These findings are interesting because sirtuins help connect cellular metabolism with circadian regulation. While increased gene expression does not necessarily translate into greater protein activity or slower aging, again, these preliminary findings do complement user experiences, many of which have noted a shift in their biological aging markers with consistent use of NANO SOMA®.
The Takeaways
The altered expression of several genes in the presence of Metadichol is noteworthy because the affected genes help coordinate important cellular activity in regards to our circadian rhythms, biological timing, and even our energy metabolism.
However, laboratory changes in gene expression do not necessarily translate into measurable health benefits. And while the study did not investigate sleep quality, energy levels, circadian synchronization, or other clinical outcomes, these results do reflect many user experiences, and we look forward to further research on how these cellular changes may support healthy circadian function* and what that might mean for human health going forward.
Research reference
Raghavan, P.R. (2024). Metadichol®-induced expression of circadian clock transcription factors in human fibroblasts. Medical Research Archives, 12(6).
DOI: https://doi.org/10.18103/mra.v12i6.5371
Are You Ready To See What It Can Do For You?
Tap the button below and discover how you can!
*These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose or prescribe for any medical condition, nor to prevent, treat, mitigate, or cure such condition(s). If you have any illness or medical condition, consult your healthcare provider.
